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Revista de Gastroenterología del Perú

Print version ISSN 1022-5129


CEDRON-CHENG, Hugo; SICCHA SINTI, Christian  and  TAGLE ARROSPIDE, Martín. Improvement of clinical course of liver cirrhosis due to chronic hepatitis C after sucessful treatment with direct acting antivirals. Rev. gastroenterol. Perú [online]. 2021, vol.41, n.4, pp.257-260. ISSN 1022-5129.

Direct-acting antivirals are new drugs, highly effective and safe against chronic hepatitis C. However, despite of hepatitis C erradication in patients with decompensated liver cirrhosis, their effect in improving the clinical course, reducing liver-related complications and the risk of developing portal hypertension and hepatocellular carcinoma is still controversial. We present two patients with decompensated liver cirrhosis Child B due to hepatitis C who received treatment with direct-acting antiviral drugs. After treatment, and with the confirmation of undetectable viral load - sustained viral response - both patients showed significant improvement in the clinical course of liver cirrhosis - Child A - and a decrease in the amount of liver fibrosis measured with non invasive methods.

Keywords : Hepatitis C; Antiviral agents; Fibrosis, liver.

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