Abstract

VALER, Victoria; MELENDEZ, Rosa; RIVAS, Luis  and  LEON, Inés. Endometrial mucosa histopathology and hormonal receptors in postmenopausal women receiving hormone therapy. An. Fac. med. [online]. 2005, vol.66, n.1, pp.3-10. ISSN 1025-5583.

Objectives: To determine correlation between hormone therapy and endometrial mucosa estrogen, progesterone receptors and endometrial histological pathology in postmenopausal women. Material and Methods: Forty postmenopausal women between 43 and 60 years old with climacteric syndrome received oral continuous 2 mg of 17 beta estradiol and 1 mg of noresthisterone acetate. Basal and 8 months post treatment edo metrial biopsies were processed for histopathologic and immune histochemical studies for estrogen and progesterone receptors. Results: Physiologic menopause occurred between 42 and 52 years old, average 46,4 years. Main climacteric symptoms on first consultation were arthralgia 90%, emotional lability 82,5%, dysparenta 75%, hot flashes 27,5% and relative urine incontinence 17,5%. Post treatment emotional lability was 7,5% arthralgia 5%, relative urine incontinence 5%, hot flashes 2,5%, paresthesia 2,5%, and cephalea 2,5%. The histopathologic study of basal endometrial mucosa showed simple hyperplasia in 10% and atrophy in 90%; atrophy was present in every case following treatment. Basal receptors expressed in the endometrial mucosa were ER (+) 12,5%, PR (++) 12,5%, and post-treatment ER(+) 2,5%, ER (+++) 2,5%, and PR (+) 2,5%. Conclusions: Oral daily combined therapy consisting in 2 mg of beta estradiol and 1 mg of norethisterone produced endometrial atrophy in patients with previous hyperplasia and statistical significant drop in the expression of estrogen and progesterone receptors between the basal sample and the 8th month sample.

Keywords : Menopause; estrogen replacement therapy; postmenopause; receptors, estrogen; receptors, progesterone; endometrial hyperplasia; endometrium, pathology.

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