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Anales de la Facultad de Medicina

Print version ISSN 1025-5583


GALARZA, Carlos et al. Topical capsaicin 0,075% versus menthol 1% efficacy and safety in HIV-associated eosinofilic folliculitis. An. Fac. med. [online]. 2007, vol.68, n.3, pp.244-248. ISSN 1025-5583.

Objetive: To determine efficacy and safety of capsaicin 0,075% topical therapy in the treatment of pruritus due to eosinophilic folliculitis in HIV patients with lymphocyte count CD4 (+) <250 x mm3. Design: Randomized clinical trial, double blind study. Setting: Infectious and Tropical Diseases Service and Dermatology Service, Hospital Nacional Dos de Mayo, Lima, Peru. Participants: Patients with VIH-associated eosinophilic folliculitis. Interventions: Forty patients with HIV-associated eosinophilic folliculitis were randomly distributed in two groups: group 1 included 20 patients that received sample 1 and group 2, 20 patients that received sample 2. Patients received capsaicin 0,075% and menthol 1% treatments (marked as sample 1 and sample 2). Instructions on topical use each 6 hours were given to patients. Visits were programmed to evaluate efficacy and monitor adverse events by study drugs. Main outcome measures: Capsaicin and menthol administration clinical outcome. Results: We found good response in 90% of patients receiving capsaicin 0,075% (18/20) versus 40% of the group treated with menthol 1% (88/20), with significant statistical difference (p= 0,001), OR = 0,074% (IC 95%: 0,013 - 0,411). Topical therapy efficacy was altered by CD4 lymphocyte count (p< 0,001); otherwise the occurrence of opportunistic diseases (p= 0,252) did not affect therapy efficacy. There were local adverse events (erithema and heat) in 3 patients (15%) who received capsaicin 0,075% and only in one patient (5%) of group 2 (menthol) who presented erithema (5%), with no significant statistical difference (p> 0,05). Conclusions: Capsaicin topical therapy is effective and safe in the treatment of pruritus in HIV-associated eosinophilic folliculitis.

Keywords : Folliculitis; HIV; capsaicin; pruritus; menthol.

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