SciELO - Scientific Electronic Library Online

vol.68 issue4Effect of glycerol on catalysis by low molecular weight acid phosphatase from alpaca liver (Lama pacos)Val108/158Met polymorphism in the catechol-o-methyl transferase (COMT) dopaminergic gene in mestizo Peruvian population and its importance in neuropsychiatric studies author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Anales de la Facultad de Medicina

Print version ISSN 1025-5583


HUAMAN, Oscar; ARNAO, Inés; BEJAR, Elsa  and  SANDOVAL, Miguel. Bixa orellana (achiote) hydroalcoholic liofilized leaves effect on rats’ gastric secretion. An. Fac. med. [online]. 2007, vol.68, n.4, pp.314-320. ISSN 1025-5583.

Objective: To determine the effect of Bixa orellana (achiote) leaves hydroalcoholic extract on non-protein sulphydryles groups (NP-SG), gastric mucus pH and gastric secretion total acidity. Design: Prospective, analytical-experimental and transversal study. Setting: Biochemistry and Nutrition Research Centre, Faculty of Medicine, Universidad Nacional Mayor de San Marcos. Biologic material: To determine the effect of the extract on gastric mucosa we used the pyloric ligation model proposed by Vissher and modified by Sandoval. For NP-SG determination Sadlak and Lindsay method was used, Corne’s method for gastric mucus production, pH and total acidity potentiometer by titration with NaOH. Main outcome measures: Levels of sulphydryle non-protein groups (NP-SG), gastric mucus, pH and total acidity. Results: Bixa orellana leaves hydroalcoholic extract NP-SG increased in 133% and 168% (p <0,01) at 100 and 200 mg/kg doses and increased mucus production in 39,4% and 44,9% respectively at 200 and 400 mg/kg doses (p<0,01). Only in the group receiving the 400 mg/kg dose there was a significant pH decrease (p<0,05). On the other hand, at 100, 200 and 400 mg/kg extract doses total acidity increased 62,3%, 58,2% and 166,6% respectively (p<0,01). Conclusions: Treatment with Bixa orellana leaves extract increases the production of mucus and GS-NP but does not inhibit total acidity.

Keywords : Bixa orellana; gastric mucosa; stomach ulcer; plant extracts.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License