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Anales de la Facultad de Medicina

Print version ISSN 1025-5583


VALLE, Rubén; VALENCIA, Víctor  and  HUAMAN-MUNANTE, José. Neurofibromatosis type 1 associated to peripheral nerve sheath and colon malignant tumor. An. Fac. med. [online]. 2009, vol.70, n.3, pp.211-216. ISSN 1025-5583.

Neurofibromatosis type 1 is a dominant autosomal disease caused by mutation of the neurofibrin gene located in chromosome 17q11.2. This disease presents a variety of clinical manifestations and predisposition to develop tumors, leading to high mortality. We report the case of a patient with neurofibromatosis type 1 diagnosis who developed a malignant tumor of peripheral nerve sheath and colon cancer. The authors review the literature as well as the clinical factors, imaging and histological features associated to neurofibromas malignant transformation.

Keywords : Neurofibromatosis 1; neurofibroma; sarcoma; neoplasms; colon.

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