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Anales de la Facultad de Medicina

Print version ISSN 1025-5583


CALLEGARI M, Andrés; ALVAREZ-FALCONI, Pedro P.  and  CESPEDES, Edmundo. Changes in blood pressure and heart rate by ketamine with and without succinylcholine. An. Fac. med. [online]. 2011, vol.72, n.2, pp.131-135. ISSN 1025-5583.

Introduction: Ketamine is used as a general anesthetic as well as for anesthesia induction and analgesia. Objectives: To assess modifications in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) caused by ketamine, and if there is any influence of succinylcholine. Design: Comparative and observational study. Setting: Maison de Santé Clinic, Lima, Peru. Participants: Patients receiving ketamine. Interventions: Ketamine was used as a single drug for general anesthesia and for induction. Twelve patients were considered for each modality. The twelve first patients received ketamine, 2 mg/kg IV, and SBP, DBP and HR were measured before and after administering the drug. The second group received ketamine plus succinylcholine, and same parameters were measured. Main outcome measures: SBP, DBP, and HR variations. Results: Following ketamine injection in the first twelve patients there were elevations in SBP 26 ± 3 mmHg, p < 0,001, DBP 19 ± 3 mmHg, p < 0,001, and HR 15 ± 3 per minute, p < 0,001. In the second group after ketamine plus succinylcholine administration there were increases in SBP 28 ± 3 mmHg, p < 0,001, DBP 18 ± 2 mmHg, p < 0,001, and HR 13 ± 1 per minute, p < 0,001. There were no statistically significant differences when comparing both groups, i.e. succinlycholine did not have any influence in modifying the aforementioned parameters. Conclusions: Increases in blood pressure and heart rate induced by ketamine were not affected by succinylcholine.

Keywords : Ketamine; succinylcholine; anesthesia; blood pressure; heart rate.

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