Abstract

ARIAS-RODRIGUEZ, Rody et al. Satureja brevicalyx ‘wayra muna’ leaves hydroalcoholic extract neuroprotection in a hyperoxia and ischemia-hypoxia animal model. An. Fac. med. [online]. 2012, vol.73, n.3, pp.215-220. ISSN 1025-5583.

Objectives: To determine Satureja brevicalyx ‘wayra muna’ leaves hydroalcoholic extract neuroprotective effect in rats subjected to hyperoxia and its progeny to hypoxia ischemia. Design: Experimental. Setting: Department of Experimental Surgery, National Institute of Child Health, and Biochemistry and Nutrition Research Center Laboratory, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Rattus novegicus Holtzman strain, Satureja brevicalyx ‘wayra muna’ dry leaves. Interventions: Treatment with the extract had two models: hyperoxia in adult female rats and hypoxia in the offspring of rats treated. Both ANOVA and Tukey test were performed. Main outcome measures: Superoxide dismutase (SOD) activity, total glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels. Results: Rats treated with the extract showed significant decrease in TBARS and participation of GSH and SOD. Conclusions: Our results suggest that Satureja brevicalyx hydroalcoholic extract exerts neuroprotective effect in hyperoxia and hypoxia conditions by alleviating experimental lipid peroxidation, an oxidative damage parameter, with participation of GSH and SOD activity as antioxidant defense mechanisms.

Keywords : Neuroprotection; oxidative stress; lipid peroxidation; superoxide dismutase; glutathione; hyperoxia; hypoxia; Satureja brevicalyx.

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