SciELO - Scientific Electronic Library Online

 
vol.73 número3Homocisteína en mujeres menopáusicas de LimaVariabilidad genética de la respuesta inflamatoria: I. Polimorfismo -511 C/T en el gen IL1β en diferentes subpoblaciones peruanas índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Bookmark


Anales de la Facultad de Medicina

versión impresa ISSN 1025-5583

Resumen

ARIAS-RODRIGUEZ, Rody et al. Satureja brevicalyx ‘wayra muna’ leaves hydroalcoholic extract neuroprotection in a hyperoxia and ischemia-hypoxia animal model. An. Fac. med. [online]. 2012, vol.73, n.3, pp. 215-220. ISSN 1025-5583.

Objectives: To determine Satureja brevicalyx ‘wayra muna’ leaves hydroalcoholic extract neuroprotective effect in rats subjected to hyperoxia and its progeny to hypoxia ischemia. Design: Experimental. Setting: Department of Experimental Surgery, National Institute of Child Health, and Biochemistry and Nutrition Research Center Laboratory, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Rattus novegicus Holtzman strain, Satureja brevicalyx ‘wayra muna’ dry leaves. Interventions: Treatment with the extract had two models: hyperoxia in adult female rats and hypoxia in the offspring of rats treated. Both ANOVA and Tukey test were performed. Main outcome measures: Superoxide dismutase (SOD) activity, total glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels. Results: Rats treated with the extract showed significant decrease in TBARS and participation of GSH and SOD. Conclusions: Our results suggest that Satureja brevicalyx hydroalcoholic extract exerts neuroprotective effect in hyperoxia and hypoxia conditions by alleviating experimental lipid peroxidation, an oxidative damage parameter, with participation of GSH and SOD activity as antioxidant defense mechanisms.

Palabras llave : Neuroprotection; oxidative stress; lipid peroxidation; superoxide dismutase; glutathione; hyperoxia; hypoxia; Satureja brevicalyx.

        · resumen en Español     · texto en Español     · pdf en Español