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Anales de la Facultad de Medicina

Print version ISSN 1025-5583


NEXAR-QH, Job  and  SILLO-SURCO, Jhon. Vasodilator and vasoconstriction inhibitor effect of Olea europaea (olive) leaf hydroalcoholic extract on rat aortic rings. An. Fac. med. [online]. 2013, vol.74, n.4, pp.285-290. ISSN 1025-5583.

Objectives: To determine the vasodilator and anti-vasoconstrictor effect of Olea europaea (olive) leaf hydroalcoholic extract on rat aortic rings and the mechanism involved. Design: Experimental. Location: Research and Scientific Development Center, Faculty of Medicine, Universidad Nacional de San Agustin, Arequipa, Peru. Biological material: Leaves of Olea europaea and aortic rings of Rattus norvegicus, swiss albina variety. Interventions: Hydroalcoholic extract was obtained from Olea europaea leaves. Rat aortic rings were placed in isolated organ chambers and the vasomotor activity was recorded with isometric tension transducer. Maximum basal contraction occurred at CaCl2, and 6 mM vasodilator effect was determined at 25, 50, and 100 mg/mL doses of the hydroalcoholic extract. 1H-[1,2,4] oxadiazole [4,3-alquinoxalin-1-one] (ODQ) and nifedipine were used to determine the mechanism of action. We compared the inhibition of vasoconstriction after incubation for 30 minutes with the extract 100 mg/mL and with captopril 10 µM. Main outcome measures: Percentage of vasodilation and vasoconstriction. Results: There was vasodilatation of 7.20 ± 1.49%, 9.84 ± 1.42%, and 12.31 ± 1.16% for respectively 25, 50, and 100 mg/mL doses of hydroalcoholic extract; it was significant at doses of 100 mg/ mL. Vasodilation increased after administration of ODQ 100 mM. Vasodilation was inhibited after incubation with ODQ 100 mM plus nifedipine 5 µM. No significant difference was found between vasoconstriction inhibition with captopril 10 µM or extract 100 mg/mL. Conclusions: Olea europaea leaves hydroalcoholic extract at 100 mg/mL dose had calcium channel blockade-vasodilator effect and vasoconstriction inhibitory effect on rat aortic rings.

Keywords : Calcium channels; plant extracts; hypertension; Olea europaea; vasodilation.

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