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Anales de la Facultad de Medicina

Print version ISSN 1025-5583


CRIBILLEROS BARRENECHEA, Jorge Renato; HERRERA SOLIS, Teófilo  and  ARROYO ACEVEDO, Jorge Luis. Carcinoembryonic antigen in recurrence and survival of patients with resection of colorectal cancer. An. Fac. med. [online]. 2014, vol.75, n.2, pp.137-143. ISSN 1025-5583.

Introduction: Carcinoembryonic antigen (CEA) has been associated with advanced stage, poor survival and early detection of recurrent colorectal cancer (CRC). Objectives: To determine relation between serum CEA and recurrence and survival of patients with curative resection of colorectal cancer. Design: Retrospective, correlational and explanatory study. Setting: Department of General Surgery, Service of Colon and Rectum, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Peru. Participants: Patients with curative resection of CRC. Methods: Patients with curative resection of CRC at Rebagliati Hospital during years 2000-2003 were followed until 2010. T test mean differences was used for variables quantitative comparison, and Kaplan-Meier method and Cox regression survival analysis techniques were also used. Main outcome measures: Patients recurrence and survival. Results: Increased serum CEA in the pre and postoperative periods was related to significant increased recurrence of colorectal cancer (p <0.05). Survival in patients with pathological CEA was significantly lower than in patients with standard CEA (p <0.05). Conclusions: Elevated serum carcinoembryonic antigen was related to increased colorectal cancer recurrence. Serum CEA values in the preoperative period would predict survival.

Keywords : Carcinoembryonic antigen; recurrence; survival.

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