Resumo

SANDOVAL VEGAS, Miguel Hernán et al. Antioxidant and cytoprotector effects of Solanum tuberosum ‘papa’ tocosh in gastric mucose in experimental animals. An. Fac. med. [online]. 2015, vol.76, n.1, pp.15-20. ISSN 1025-5583.  http://dx.doi.org/10.15381/anales.v76i1.11070.

Tocosh is a nutritious product obtained by an Andean preservation technique with nutritive and therapeutic properties. Objective: To demonstrate antioxidant and cytoprotector effects of Solanum tuberosum ‘papa’ tocosh in the gastric mucosa of experimental animals. Design: Experimental. Institution: Biochemistry and Nutrition Research Center, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biologic material: Dry and grounded administered to albino rats. Interventions: Six groups of male albino rats (200 ± 50 g) were divided in: (GI) NaCl 0,9% solution, 10 mL/kg; (GII) ethanol 70% 10 mL/kg; (GIII, IV y V) Tocosh equivalent to 900 mg/kg, 1 800 mg/kg, and 2 700 mg/kg respectively, and (GVI) sucralfate 30 mg/kg. One hour after, in all cases injury with ethanol 70° 10 mL/kg was induced and gastric tissue was obtained by abdominal laparotomy. Main outcome measures: Percentage of gastric cytoprotection in digitalized image by image analysis software for plant disease quantification, and antioxidant ability by lipoperoxidation spectrophotometric method of reactive species reaction to thiobarbituric acid (TBARS). Results: The phytochemist progress identified phenolic compounds, alcaloids, triterpenoids and steroids, reducing sugars and free aminoacids as secondary metabolites. The 2 700 mg/kg and 900 mg/kg doses resulted respectively in 0.72 and 1.81 nmol/g lipoperoxidation tissue. The 1 800 mg/kg doses protected 97% of the gastric mucosa, 2 700 mg/kg 95% and the 900 mg/kg, 88% (p<0.05). The 1 800 mg/kg doses exhibited better cytoprotector effect and the 2 700 mg/kg doses better antioxidant activity, compared with sucralfate 30 mg/kg. Conclusions: Solanum tuberosum ‘papa’ tocosh showed cytoprotector effect and antioxidant activity.

Palavras-chave : Tocosh; mucoprotection; gastric mucosa; Solamun tuberosum.

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