Abstract

GOMEZ-HERREROS, César et al. Assessment of hydrogen sulfide innocuousness on Cavia porcellus (guinea pigs) cardiac tissue. An. Fac. med. [online]. 2016, vol.77, n.3, pp.213-217. ISSN 1025-5583.

Introduction. Hydrogen sulfide (H₂S) is toxic and lethal to mammals at high concentrations, but at low concentrations may be beneficiai. Objective. Assessment of hydrogen sulfide harmlessness on Cavia porcellus (guinea pigs) cardiac tissue in vivo. Design. Experimental study. Setting. School of Medicine Pharmacology Laboratory, Universidad Nacional Mayor de San Marcos, Lima, Peru, and Experimental Surgery Unit at Instituto Nacional de Salud del Niño, Lima, Peru. Biological material: Twenty one Cavia porcellus (guinea pigs). Interventions. The experimental design considered three groups: 1) Clean air (control); 2) H₂S at 80 ± 20 ppm (experimental, gaseous exposure); 3) Sevoflurane 1.5% (gold standard). Animals were placed in a hood where they were nebulized for twenty minutes; at the end of the exposure, the heart was withdrawn for histopathological study. Main outcome measures. Cardiac cell injury. Results. H S exposure did not induce abnormalities; otherwise, exposure to sevoflurane showed moderate impairment in 3 of 7 heart tissues, but tRe result was not significant (p > 0.05) for this group. Conclusion. H₂S at 80 ± 20 ppm was innocuous on Cavia porcellus tissue cardiaco

Keywords : Hydrogen Sulfide; Sevoflurane; Guinea Pigs; Innocuousness.

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