Abstract

RUNCIMAN GOZZER, Thanya  and  CARRACEDO GONZALES, Carlos. Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer. An. Fac. med. [online]. 2018, vol.79, n.4, pp.327-330. ISSN 1025-5583.  http://dx.doi.org/10.15381/anales.v79i4.15639.

Resistance to third-generation tyrosine kinase inhibitors (TKI) is an increasingly frequent event in clinical practice; however, the exact mechanisms by which tumor cells develop such resistance allowing their survival are unknown. A case of resistance to osimertinib (AZD9291) in non small cell lung cancer, evidenced by next generation sequencing (NGS) and its possible therapeutic approach is described.

Keywords : Drug Resistance; Tyrosine; Lung Neoplasms.

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