Abstract

LOSADA, Martha; POCHE, Alba; VELASQUEZ, Victoria  and  SANCHEZ, Víctor. Histopathological and immunohistochemical (IHC) diagnosis of non-Hodgkin lymphoma (LNH) in a female canine. Rev. investig. vet. Perú [online]. 2020, vol.31, n.2, e17939. ISSN 1609-9117.  http://dx.doi.org/10.15381/rivep.v31i2.17939.

The clinical case of a 2-year-old female canine patient, French Poodle breed, who had presented three evident oestrous in a period of less than six months, according to the owner, is described. In the initial clinical examination, a patient with apoplexy signs was observed and in the examination of the genitourinary apparatus, abundant vaginal serobloody secretion was evident. The ultrasound study of the inguinal region reveals the presence of a non-specific rounded hyperechogenic structure with multiple oncogenic areas suggestive of pyometra. Cytology was performed by ultrasound-guided mass puncture that showed as a presumptive diagnosis of round cell neoplasia. An exploratory laparotomy is performed in which a mass of reddish colour in the cervix of 8 cm in diameter and 3 cm wide was evident. Histopathological study of the tumour mass sample gave a definitive diagnosis of malignant neoplasm of large cells consistent with intermediate grade non-Hodgkin lymphoma. The confrontation with CD3 biomarkers yielded a severe reactivity result with extensive multifocal distribution. Given the casuistic conditions, euthanasia was performed. The autopsy showed metastatic foci in the ribs.

Keywords : large cells; biomarkers; CD3; canine; female; cervix.

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