Resumo

TAPIA A, Christian et al. Temporary course of fluoxetine and norfluoxetine in German Shepherd and Akita Inu dogs. Rev. investig. vet. Perú [online]. 2020, vol.31, n.4, e17635. ISSN 1609-9117.  http://dx.doi.org/10.15381/rivep.v31i4.17635.

The pharmacokinetics of fluoxetine were evaluated in two phylogenetically distant dog breeds. The quantification method was fine-tuned and validated through the mean, standard deviation and coefficient of variation (CV) for each sampling point. The CV values were around 2%. The detection limit was 3.36 ng/ml and corresponded to three times the signal noise of the blank sample. The limit of quantification (LOQ) was 10.53 ng/ ml. The chromatographic analysis indicated that the maximum concentrations of fluoxetine were reached at two hours post-administration (Akika Inu: 41.8 ± 0.6 ng/ml; German Shepherd: 45.3 ± 1.4.0 ng/ml), while the minimum concentrations were reached at 80 hours (Akika Inu: 3.9 ± 0.1ng/ml; GermanShepherd: 3.9 ± 0.1 ng/ml).Asignificant difference between breeds was only found in the values reached at 2 h post-administration (p<0.05). Results may indicate that due to the differences in the time curve, drug management might be different between phylogenetically different breeds.

Palavras-chave : fluoxetine; norfluoxetine; time course; behaviour; clinical ethology.

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