Abstract

GAVIDIA, Rodolfo. Sobre el sinergismo de los efectos vasculares de Stricnina y Cardiazol. Rev. perú. med. exp. salud publica [online]. 1943, vol.2, n.1, pp.47-55. ISSN 1726-4634.

A study was made of the sinergism of Cardiazol and strychnine on the arterial blood pressure of 29 dogs treated with curare. 1. In the cases in which the hypertensive action of the strychnine was very small o absent (50 % of the total experiments) there was synergism between that drug and the Cardiazol. 2. In the cases where the strychnine caused strong hypertensive action and where the Cardiazol was injected during the hypertension, there was no synergism. On the contrary, the cardiazolic hypertension in the strychnine dog was in this case very inferior to the cardiazolic hypertension of the non-strychnized dog. 3. The strychnic hypertension lasts longer than the cardiazolic hyper - tension. 4. Upon the sinus-carotid reflex the strychnine and the cardiazol have stimulant action only in the cases in which the initial reflex is weak. 5. Upon the oculo-cardiac reflex the results are very variable. 6. The bladder is very sensitive to cardiazol and strychnine, always reacting with an intense contraction, and even at subconvulsivant doses. It was possible to demostrate synergism in this action between these drugs.

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