Abstract

GUTIERREZ-NORIEGA, Carlos. Hipnoticos corticales y basilares y acciones anticonvulsivantes. Rev. perú. med. exp. salud publica [online]. 1943, vol.2, n.2, pp.75-112. ISSN 1726-4634.

Differences of the so-call cortical and subcortical hypnotics are studied from the viewpoint of their anticonvulsant action. 1. The anticonvulsant action of some subcortical hypnotics (barbiturates and urethane) is considerably stronger than the anticonvulsant action of some cortical hypnotics (alcohol, aldehydes, bromides, ether), with the exception of magnesia sulphate, classified in the subcortical group, which was found to have very weak anticonvulsant action. 2. A hypnotic of the cortical group (chloralose) remarkably increases the reflex excitability of the central nervous system, and diminishes the amount of metrazol, coramine and strychnine required to produce clonic convulsions. Potentation between this hypnotic and analeptics is demostrable. 3. Synergism between metrazol and strychnine to produce clonic convulsions is much more noteworthy in the animal anesthetized with chloralose than in the unanesthetized animal. 4. Significant quantitative and q1alitative differences were shown between the convulsions of the unansthetized animal and the convulsions of the animal anesthetized with chloralose. In the latter case tonic convulsions were not found to occur, (but clonic convulsions in the animal anesthetized with chloralose are considerably more prolongued than clonic convulsions in unanesthetized animal). 5. During the narcosis produced by barbiturates the depressive action occurs in the total nervous system. During the narcosis produced .by Chloralose an increase of excitability of some cortical and subcortical centers is demostrable. The possility that internuncial system is stimulated, is discussed. All the narcotics used as hypnotics do not paralyze the central nervous system in essentially the same way.

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