Abstract

GUTIERREZ-NORIEGA, C  and  ZAPATA ORTIZ, V. Una nueva acción farmacológica de la cocaína la acción anticonvulsivante. Rev. perú. med. exp. salud publica [online]. 1945, vol.4, n.2, pp.59-100. ISSN 1726-4634.

The effects of Cocaine on the central nervous system have been compared with the action of other neurostimulants. The following results have been recorded: 1. At subconvulsive doses Cocaine acts antagonistically to convulsive doses of Metrazol. In mice and quinea-pigs it was demonstrated that Cocaine diminishes the rate of metrazolic convulsions as well as other reactions of the central nervous system to Metrazol stimulation. It was also ascertained that Cocaine reduces the death rate of mice that have received lethal doses of Metrazol. 2 In dogs, subconvulsive doses of Cocaine diminish the length and intensity of metrazolic convulsions. It was mainly observed a reduction in the intensity and length of the tonic contractions. 3. Cocaine at subconvulsive doses acts as an antagonist to lethal and convulsive doses of Strichnin. Observations made on mice showed that Cocaine cuts down the rate and intensity of convulsions due to maximal lethal and convulsive doses of Strichnin (L. D. 100 and C. D. 100). Cocaine also checks the lethal action of toxic doses of Strichnin. 4. No antagonism or synergism was found between Cocaine and Strichnin in non-anesthesized dogs. However, in dogs under Chloralose anesthesia it was possible to show in many instances that Cocaine may check strichnic convulsions. 5. In curarized dogs no synergism or antagonism in hypertensive reactions was observed between Cocaine and other neurostimulants. However, it was demonstrated in many cases that Cocaine abolishes the hypertensive reactions connected with metrazolic convulsive discharges during epileptid seizures. Observations were also made which showed that Cocaine either weakens or abolishes some reflex vascular reactions in curarized dogs as well as dogs under the effects of some neurostimulants. 6. A discussion is made of the antagonistic action of Cocaine in relation to the action of other neurostimulant drugs studied (Metrazol and Strichnin), and a working hypothesis is suggested.

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