Resumen

YABAR VARAS, Carlos. Caracterización Molecular de la Secuencia parcialdel Gen de la Glicoproteína NS1 del Virus Dengue 1 proveniente de Máncora, Perú   . Rev. perú. med. exp. salud publica, 2000, vol.17, no.1-4, p.35-38. ISSN 1726-4634.

A 419bp-NS1 genetic region corresponding to Dengue virus 1 was characterised from an outbreak in Máncora Piura. The comparison of nucleotide sequences revealed that Peruvian isolates showed high correlation (93.32%) with a Hawaii strain. Amino acids comparisons revealed non-conservative changes into humoral response epitope domains. On the other hand, the hydropathy profile of NS1 was similar to other referential strains. The results suggest that more comparisons are needed regarding genetic identity and mutations into the epitope domain of Peruvian dengue 1 virus.

Palabras llave: Dengue virus; Viral nonstructural proteins; Base sequence; Peru.