Abstract

CIEZA Z, Javier et al. Factores de riesgo para infección por hepatitis C en dos unidades de diálisis de Lima-Perú. Rev. perú. med. exp. salud publica [online]. 2001, vol.18, n.1-2, pp.5-8. ISSN 1726-4634.

The prevalence for hepatitis C antibodies (antiHCV) has been described between 60% and 90% in peruvian hemodialysis centers. Objective: To determine variables associated to the positivity for antiVHC in hemodialysis patients in Lima-Peru. Materials and methods: In March 2000, a case-control study was designed. All 38 antiHCV positive cases and 38 negative controls from 2 dialysis units in Lima were included. Both groups were matched for age and sex. Odds ratio (OR) and their intervals of confidence (IC95%) were used to investigate the association between the dependent variable (positivity for antiHCV) and independent variables (antecedent of blood transfusions, time in hemodialysis, number of previous dialysis centers, hepatitis antecedent, australian antigen positivity, hepatitis B antibodies, previous surgery, positive hepatitis C sexual partner, turn of dialysis, transplant rejection, center of first hemodialysis. Results: The variables that reached significance in the univariante analysis were: number of blood transfusions, time in hemodialysis and the positivity for australian antigen (p<0.05). By multinornial logistic regression analisys the only variable that showed a risk for HCV infection was blood transfusions (OR: 4.8, IC95%: 1.6-14.4) The positivity for australian antigen behaved like a "protective factor" for hepatitis C infection (OR: 8.7x10-9). Conclusions: Blood transfusions are strongly associated to hepatitis C infection in peruvian hemodialysis unit patients.

Keywords : Hepatitis C/transmission; Dyalisis; Risk factors.

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