Abstract

MORALES DE SANTA GADEA, Sara; DIAZ V, Carmen; GONZALES Q, Dana  and  HUAPAYA C, Blanca. Susceptibilidad antimicrobiana del Streptococcus pneumoniae determinando la concentración inhibitoria mínima, 1999. Rev. perú. med. exp. salud publica [online]. 2001, vol.18, n.1-2, pp.35-37. ISSN 1726-4634.

Objective: To determine minimum inhibitory concentration of S. pneumoniae against the antibiotics recommended by PAHO/WHO in the treatment of acute respiratory infections. Materials and Methods: Descriptive study of S. pneumoniae cultures isolated from children under 5 years of age diagnosed with neumonia and meningitis in 7 hospitals of the country. The microdilution method for penicillin, chloramphenicol and cotrimoxazol was performed following the guidelines given by the National Committe for Clinical Laboratory Standards (NCCLS). Results: Of 30 isolates, 8 (26.7%) showed diminished susceptibility to penicillin, 4 (13.33%) showed intermediate resistance and 4 (13.3%) high resistance. Twenty one (70.0%) isolates showed resistance to the combination of trimethoprim and sulfamethoxazole and 10 (33.0%) showed resistance to chloramphenicol. Resistance to two antimicrobial agents was observed in 12 (40.0%) and multiple resistance was found in 2 (6.7%). Conclusions: This study shows the presence of strains of S. pneumoniae resistant to penicillin and other antimicrobial agents, which shows us the need to maintain an epidemiological surveillance on this bacteria.

Keywords : Streptococcus pneumoniae; Antibiotics; Microbial sensitivity tests.

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