Abstract

ESTUDIO INTERINSTITUCIONAL DESARROLLADO POR LAS INSTITUCIONES DEL MINISTERIO DE SALUD DEL PERU; EN COLABORACION CON EL INSTITUTO DE INVESTIGACION DE ENFERMEDADES TROPICALES DE LA MARINA DE LOS ESTADOS UNIDOS; LA UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS  and  LA UNIVERSIDAD PERUANA CAYETANO HEREDIA. Etiologic profile of febrile syndrome in areas at a high risk for transmission of infectious diseases with an impact in public health in Peru. 2000-2001. Rev. perú. med. exp. salud publica [online]. 2005, vol.22, n.3, pp.165-174. ISSN 1726-4634.

Objectives: To know the etiologic profile in patients with febrile syndrome reported as negative for Bartonella infection or with a negative result in thick smears for malaria in two pilot areas (Northern Coast and Eastern Jungle in Peru). Materials and methods: A longitudinal and descriptive study was performed between May 2000 and July 2001 in four health facilities: Chiclayito and Salitral in Piura, Yurimaguas Hospital, and San Juan Health Center in Loreto. Febrile patients between 5 and 65 years old were included with negative smears for Bartonella or negative thick smears for malaria. The following tests were performed in the samples obtained: indirect immunofluorescence for typhus (only in Piura), ELISA IgM for leptospirosis and ELISA IgM-IgG for dengue fever, yellow fever, Mayaro, Oropuche and Venezuelan equine encephalitis (VEE). Results: Isolation of dengue fever virus was achieved in 27 (6,3%) patients, VEE virus was found in five patients, and group C virus was found in one patient. Dengue fever 2 and 3 viruses were identified in Chiclayito. VEE and group C virus were isolated in San Juan patients. Anti-dengue fever IgM was found in 43 (9,6%) patients, and yellow fever IgM was found in 21 (4,7%) patients, most of them from Yurimaguas. Also, VEE IgM was found in seven patients, Mayaro virus IgM was found in one and Oropuche virus IgM was found in four. Leptospirosis was the second most frequent cause of febrile syndrome (3,8%); while typhus was confirmed using indirect immunofluorescence in five Chiclayito patients. Conclusions: Studying the etiology of febrile syndrome allowed us to detect circulation of EEV virus, the presence of dengue fever 3 virus in Peru and also the prevalence of arboviral infections as a cause of febrile syndrome in the Peruvian Northern Coast and Eastern Jungle in the absence of epidemic activity.

Keywords : Syndromic surveillance; Febril syndrome; Dengue; Yellow Fever; Leptospirosis; Arbovirus; Tifus; Peru (source: DeCS BIREME)..

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