Revista Peruana de Medicina Experimental y Salud Publica
versión impresa ISSN 1726-4634
ASENCIOS S, Luis et al. Niveles de resistencia a drogas antituberculosas en pacientes con infección VIH / Tuberculosis, Lima, 1998-2001. Rev. perú. med. exp. salud publica [online]. 2006, vol.23, n.2, pp. 98-103. ISSN 1726-4634.
Objective: To determine resistance rates to first-line antituberculous drugs in clinical samples from patients co-infected with the human immunodeficiency virus (HIV) and M. tuberculosis (TB) in five hospitals in Lima between 1998-2000. Materials and methods: A descriptive study including samples sent for culturing Mycobacterium tuberculosis in patients co-infected with HIV-TB. Susceptibility tests for isoniazid (H), streptomycin (S), ethambutol (E), and rifampin (R) were performed using the proportion method and Waynes method for pyrazinamide (Z). Results: Out of 523 samples, 78,2% were from male patients, and 72,7% were from naive patients. Overall primary resistance and multidrug-resistance (MDR) rates were 55,8% and 32,1%, respectively; and overall acquired resistance and MDR rates were 93,0% and 74,8%, respectively. Primary resistance rates were: H, 42,1%; R, 35,0%; S, 35,3%; E, 19.0%, and Z, 24,5%, respectively; and acquired resistance rates were: h, 85,3%; R, 78,3%; S, 64,4%; E, 42,0%; and Z, 46,2%. Conclusion: There are high resistance rates to antituberculous drugs and MDR TB in patients co-infected with HIV and TB in Lima hospitals.
Palabras llave : Mycobacterium tuberculosis; HIV; Drug resistance; Peru.