Resumo

ASTUVILCA, Juan et al. Incidence and associated factors to adverse reactions of the initial antiretroviral treatment in patients with HIV. Rev. perú. med. exp. salud publica [online]. 2007, vol.24, n.3, pp.218-224. ISSN 1726-4634.

The high incidence of adverse reactions to the high activity antiretroviral treatment (HAART) in patients with HIV/AIDS, can affect their quality of life and adherence to the treatment. Objectives: To determinate the incidence of adverse reactions to the initial HAART and to identify the factors associated to the occurrence of adverse reactions when receiving this therapy. Material and methods: Historic cohort study. The population was conformed by all the HIV-infected adult patients (≥18 years old) receiving HAART for the first time in "Arzobispo Loayza" National Hospital. 353 clinic histories were reviewed and their respective control cards. The following for 360 days alter the first prescription was realized. Results: It was found an accumulated incidence of 66,7% adverse reactions to initial HAART and an incidence density of 9,1 events of adverse reactions for 10 persons-year of follow-up (95%CI: 8,1-10,1); being anemia (23,4%), nausea (20,6%) and rash (17,2%) the most frequent adverse reactions. It was found significant associations with the following factors: drug use (OR 2,40; 95%CI: 1,01-5,67); alcohol consume (OR 0,32; 95%CI: 0,19-0,55) and AIDS stadium (OR 0,20; 95%CI: 0,04-0,95). Conclusions: There is a high incidence of adverse reactions to initial HAART, being anemia the most frequent. The drug consume is a risk factor to present adverse reactions.

Palavras-chave : HIV/AIDS; Highly active antiretroviral therapy; Adverse drug reaction reporting system; Incidence.

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