Revista Peruana de Medicina Experimental y Salud Publica
versión impresa ISSN 1726-4634
SOTO, Alonso et al. Pragmatic clinical trial in trauma: crash 2 trial in Perú. Rev. perú. med. exp. salud publica [online]. 2008, vol.25, n.1, pp. 138-143. ISSN 1726-4634.
CRASH-2 is a pragmatic clinical trial which evaluates the efficacy of a widely available, low cost antifibrinolytic for the prevention of mortality and bleeding in patients with trauma. In this article we present some issues related to the magnitude of the problem as well as the need for research in trauma relevant to the Peruvian context. The rationale for the CRASH-2 trial and the Peruvian experience up to date are also discussed.
Palabras llave : Antifibrynolitics; Tranexamic acid; Clinical trial; Traffic accident.