SciELO - Scientific Electronic Library Online

vol.25 issue2Effect of polivalent bothropic antivenom on phospholipase a2, l- amino acid oxidase and hyaluronidase from peruvian snake venom author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634


YARLEQUE, Armando et al. Action of polivalent bothropic antivenom on proteolytic activities from peruvian snake venoms. Rev. perú. med. exp. salud publica [online]. 2008, vol.25, n.2, pp.169-172. ISSN 1726-4634.

Peruvian snake venoms responsible for most of ophidism accidents, contain proteolytic enzymes that can degrade tissue and plasmatic proteins, as well as cause hypotension and blood coagulation. Objectives. The inhibiting capacity of liquid polyvalent bothropic antivenom produced by Instituto Nacional de Salud (INS), has been evaluated on caseinolytic, coagulant and amidolytic activities on Bothrops atrox, Bothrops brazili, Bothrops pictus and Bothrops barnetti venoms. Material and methods. Using in each case casein, bovine fibrinogen and the chromogenic substrate BApNA respectively, measuring changes in values of enzymatic activity at ½, 1 and 2 doses of either natural and heating (incubated at 37 °C during five days) antivenom. Results. Caseinolytic activity is more resistant to inhibition especially by the natural antivenom, amidolytic activity was severely inhibited mainly in B. pictus and B. atrox venoms. Also coagulant activity was totally inhibited in B. pictus venom, being high on B. brazili and B. atrox venoms. For coagulant and amidolytic activities, heated antivenom was less effective than natural one. Conclusions. The bothropic antivenom produced by INS is effective to inhibit the proteolytic activity from Peruvian snake venoms tested.

Keywords : Snake venoms; Proteases; Antivenins; Snake bite.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License