SciELO - Scientific Electronic Library Online

vol.27 issue2Marine bacteria producing antibacterial compounds Isolated from inter-tidal invertebratesActions and strategies for the prevention and control of road traffic injuries: peruvian experience by levels of prevention author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634


SUAREZ, Víctor J. et al. Effect of levonorgestrel in the ovulation, endometrium, and spermatozoa for emergency oral contraception. Rev. perú. med. exp. salud publica [online]. 2010, vol.27, n.2, pp.222-230. ISSN 1726-4634.

There is wide controversy about the mechanism of action of the levonorgestrel used for emergency oral contraception, and many organizations, both scientific as well as from the civil society, show their discrepancy with its use, due to its possible action as an abortion- inducer. In order to evaluate the scientific evidence available on the mechanisms of action of the levonorgestrel used for emergency oral contraception (EOC), a systematic revision was performed in the Medline and Cochrane library databases. We found 444 articles. After reviewing the abstracts, we selected 22 articles, whose complete texts were evaluated. We found that the main mechanism of action of the levonorgestrel, given at the doses recommended for EOC, is the inhibition or retardation of the ovulation, it doesn’t affect the spermatozoa in their migration or egg-penetration capacities. No morphological or molecular alterations in the endometrium that could interfere with the implantation of the fertilized egg have been demonstrated. There is no actual scientific evidence available supporting that the use of levonorgestrel for EOC is abortive.

Keywords : Postcoital contraception; Levonorgestrel; Endometrium; Ovulation; Spermatozoa.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License