Revista Peruana de Medicina Experimental y Salud Publica
ISSN 1726-4634 versão impressa
PINTO, Miguel E, BANDA, Claudia e SEAS, Carlos. Aspergilosis pulmonar secundaria a neutropenia inducida por metimazol: reporte de un caso. Rev. perú. med. exp. salud publica, jun. 2012, vol.29, no.2, p.255-258. ISSN 1726-4634.
A 48-year old woman with a recent diagnosis of Graves’ disease arrived at the emergency room with fever, palpitations, and a sore throat. Her regular treatment included methimazole. On admission, laboratory results showed suppressed TSH, elevated free thyroxine, and neutropenia. She was admitted and started on antibiotics and granulocyte-macrophage colony stimulating factor (gm-csf). After ten days, the patient developed leukocytosis, fever, and hemoptysis. Chest CT scan showed a lung cavity with multiple nodules in the upper right lobe. Cultures from a lung biopsy were positive for Aspergillus Fumigatus and Aspergillus Flavus. Amphotericin B was started but then switched to voriconazole, with both treatments failing to result in clinical improvement. The patient died of multi-organ failure
Palavras-chave: Aspergillus; Pulmonary aspergillosis; Neutropenia; Methimazole; Antithyroid agents.
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