SciELO - Scientific Electronic Library Online

vol.30 issue1Scientific production and cancer-related collaboration networks in Peru 2000-2011: a bibliometric study in Scopus and Science Citation IndexRespiratory symptoms caused by the use of electrocautery in physicans being trained in surgery in a Mexican hospital author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634


CASTRO-MUJICA, María del Carmen  and  SULLCAHUAMAN-ALLENDE, Yasser. Molecular subtypes of PML/RARα _in patients with acute promyelocytic leukemia. Rev. perú. med. exp. salud publica [online]. 2013, vol.30, n.1, pp.37-40. ISSN 1726-4634.

The objective was to describe the frequency of molecular subtypes of PML/RARα in patients with acute promyelocytic leukemia (APL) and their distribution according to risk of recurrence and cytomorphology. A case series was carried out, including fifty patients registered at the National Institute of Neoplastic Diseases (INEN) during 2010-2012, with molecular diagnosis of APL PML/RARα and bcr1, bcr2 and bcr3 subtypes by reverse-transcription polymerase chain reaction (RT-PCR). Bcr1 subtype was the most frequent (62%). Most patients with an intermediate risk of recurrence and hypergranular morphology were bcr1 (70%), while all patients with high risk of recurrence and hypogranular morphology were bcr3. A predominance of bcr1 subtype among the population studied can therefore be concluded, as well as the fact that there are differences in the distribution of bcr1 and bcr3 subtypes according to recurrence risk group and cytomorphology

Keywords : Leukemia; promyelocytic; acute; Gene fusion; Reverse transcriptase polymerase chain reaction.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )