Abstract

MEDEL-MATUS, Jesús S et al. Interleukin-1ß, seizures and neuronal cell death. Rev. perú. med. exp. salud publica [online]. 2013, vol.30, n.2, pp.262-267. ISSN 1726-4634.

Epilepsy is a neurological disorder affecting almost 1% of the world population. Experimental human and animal studies suggest that inflammation mediators, like cytokines, participate in the physiopathology of epilepsy. Interleukin-1beta (IL-1ß) could influence susceptibility for seizures, as well as neuronal death caused by seizures, although some findings are contradictory. This document reviews the current knowledge establishing a connection between IL-1ß, seizures and neuronal death.

Keywords : Epilepsy; Convulsions; Inflammation; Interleukin-1ß; Neuronal cell death.

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