SciELO - Scientific Electronic Library Online

vol.30 issue4Efficacy of a single dose of Albendazole for soil-transmitted helminth infections in school children of a village in Iquitos, PerúNosocomial infections associated to invasive devices in the intensive care units of a national hospital of Lima, Peru author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634


HUAMAN, Juana; RAEZ, Ernesto; QUINO, Mariano  and  RODRIGUEZ-CALZADO, Javier. Gastroprotective and antisecretory effect of a phytochemical made from matico leaves (Piper aduncum). Rev. perú. med. exp. salud publica [online]. 2013, vol.30, n.4, pp.608-615. ISSN 1726-4634.

Objectives. To determine the gastroprotective and antisecretory effect of ethanol extract from matico leaves (Piper aduncum) in animal models. Materials and methods. To evaluate the gastroprotective effect, 220 mice of the Balb C57 strain were used. They were randomized in 22 groups of ten animals each, in which the formation of gastric ulcers was induced with indomethacin. Gastroprotection was determined by evaluating three aspects: inflammation, number of hemorrhagic shocks and number of ulcers. To evaluate the antisecretory effect, 64 white male Holtzman rats were used, which were randomized in eight groups of eight animals, one control and seven groups of treatment with one extract dose level and two phytochemical dose levels. Antisecretion was obtained through the pylorus ligation. Results. Regarding gastroprotection, dichloromethane, chloroform, hexane and methanol extracts decreased inflammation to over 66% (p<0,05). The ethanolic extract shows 100% activity in reducing the number of hemorrhagic bands (p<0,05). The chloroform extract shows antiulcer activity at 75% (p<0,05). In terms of antisecretion, the phytochemical in capsules containing the ethanolic extract achieved 72% reduction of the gastric secretion volume (p<0,01) and 104,3% (p<0,01) PH increase. Conclusions. In experimental conditions, ethanolic extracts, their fractions and phytochemicals have a gastroprotective effect in mice and antisecretory effect in rats.

Keywords : Matico; Plants, medicinal; Phytotherapy; Plant extracts.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )