SciELO - Scientific Electronic Library Online

vol.31 issue1Neurotoxic effect of aqueous extract of boldo (Peumus boldus) in an animal modelHigh blood pressure and obesity in indigenous ashaninkas of Junin region, Peru author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634


TAMARIZ, Jesús H; LEZAMETA, Lizet  and  GUERRA, Humberto. Phagotherapy faced with Staphylococcus aureus methicilin resistant infections in mice. Rev. perú. med. exp. salud publica [online]. 2014, vol.31, n.1, pp.69-77. ISSN 1726-4634.

Objectives: To assess the bacteriophage activity in localized and systemic infections caused by Staphylococcus aureus resistant to methicilin (MRSA). Materials and methods. An experimental study was performed in 45 mice of the Balb/c strain divided in nine groups of five individuals. Ten naive bacteriophages were isolated through clinical samples and hospital effluents. Lytic capacity and spectrum activity was evaluated on the basis of which six phages were selected for phagotherapy trials. Additionally, a commercial bacteriophage was used. The phagotherapy was evaluated through prophylaxis, and therapy of localized and systemic infections caused by MRSA by subcutaneous and intravenous inoculation, respectively. The effectiveness of three therapeutic schemes was tested: monotherapy, phage cocktail in multiple doses and phage cocktail in a single dose. The therapeutic activity of the phages was also compared with vancomycin and clindamycin. Results. The phage cocktail and the diverse dose therapy were effective in preventing and controlling MRSA localized infections; its activity was similar to the vancomycin and clindamycin activity. The single dose phage cocktail failed to control localized infection and phagotherapy was not effective in systemic infections. Conclusions. Phagotherapy could be a viable alternative for infections caused by MRSA. Further studies that assess related aspects to phages and patient safety are required

Keywords : Bacteriophages; Methicillin-resistant Staphylococcus aureus; Mice.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License