SciELO - Scientific Electronic Library Online

vol.31 issue1A new generation of reliable clinical practice guidelines through MagicIntegration of mental health and chronic non-communicable diseases in Peru: Challenges and opportunities for primary care settings author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634


GUYATT, Gordon H  and  MALAGA, Germán. Difficulties in the interpretation of the results of biomedical research related to chronic non-communicable disease patient management. Rev. perú. med. exp. salud publica [online]. 2014, vol.31, n.1, pp.127-130. ISSN 1726-4634.

The progressive increase in the prevalence of chronic non-communicable diseases (CNCD) has generated a need to change the paradigms in interpreting research about therapeutic and disease control strategies. One aspect to keep in mind is the incorporation of risk awareness that CNCD treatment implies, which creates uncertainty in the treatment result, compared to the curative paradigm that occurs in communicable diseases where a cure is expected. Another aspect is related to clinical trials result reports, where substitute results are used frequently. For example, the therapeutic goal of reducing glycosylated hemoglobin in a diabetic patient instead of showing the results based on treatment benefit (such as prevention of myocardial infarction). Problems arise when looking for a substitute that can replace the result that really matters. That is why we must be alert to the widespread use of results grouping (composite outcomes) which while they allow studies with fewer patients with shorter follow-up times and less expense, they can generate misleading results and show presumed untrue benefits due to improper selection of components of the “composite outcomes”. In this article we draw attention to new challenges in the interpretation of scientific studies related to CNCDs

Keywords : Evidence-based medicine; Health status indicators; Therapeutic misconception; Biological markers; Clinical trials as topic.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License