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Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634


TORRES-RAMIREZ, Luis et al. Creutzfeldt-jakob disease in Peru: report of eleven cases. Rev. perú. med. exp. salud publica [online]. 2014, vol.31, n.2, pp.364-369. ISSN 1726-4634.

Creutzfeldt-Jakob disease (CJD) is a fatal neurological disease caused by pathological isoform of the human prion protein. Clinical features of six cases of the sporadic form of CJD with definitive diagnosis by histopathology, and five cases with probable diagnosis were reported in patients treated at the Peruvian National Institute of Neurological Sciences. The average age of onset in definite cases was 55.8 years and in probable cases was 59.6, mostly males. The average disease duration was 8.8 months. A typical EEG was found in 50% of definite cases and in 80% of probable. The 14-3-3 protein in cerebrospinal fluid was positive in a probable case, and typical MRI findings were observed in two probable cases. All cases studied had a typical clinical course of the disease, and it is considered as the first report of CJD in Peru

Keywords : Creutzfeldt-Jakob syndrome; Prion diseases; PrPSc proteins; Prions; Peru.

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