Abstract

LEIVA-REVILLA, Johanna et al. Effect of red maca (Lepidium meyenii) on INF-γ levels in ovariectomized rats. Rev. perú. med. exp. salud publica [online]. 2014, vol.31, n.4, pp.683-688. ISSN 1726-4634.

Objectives. Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). Materials and methods. Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts with 2.15, 4.3 and 8.6 mg polyphenols/body weight kilogram, respectively. Results. OVX rats showed low levels of IFN-γ compared to PO rats. Estradiol and red maca reversed the effect of ovariectomy on the IFN-γ levels. A positive dose-response effect of red maca on IFN-γ levels was shown (r = 0.57, p <0.05). Conclusions. Red maca administration increases levels of IFN-γ in ovariectomized rats.

Keywords : Maca; Interferon-gamma; Ovariectomy; Estradiol.

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