Abstract

CERON, Willy et al. Mesenchymal stem cells: definitions, culture and potential applications. Rev. perú. med. exp. salud publica [online]. 2016, vol.33, n.4, pp.758-771. ISSN 1726-4634.  http://dx.doi.org/10.17843/rpmesp.2016.334.2563.

In recent years, mesenchymal stem cells (MSC) have become very important due to their high plasticity and their ability to release paracrine factors able to interact with various cell types, tissues and organs. The use of MSC in regenerative medicine became of vital importance, since they do not express histocompatibility MHC molecules class II nor co-stimulant molecules, and low expression of MHC class I, will not be rejected by individuals of same species, they could be used in an autologous, and eventually, allogeneic manner. However, it is important to scientifically demonstrate many properties, including immunomodulatory ones. Having several sources of obtaining, it should be standardized the best one to ensure the purity and quality of these cells. Finally, it is important when working with these cells, that characteristics of cell culture, immunophenotyping and differentiation capacity are fully demonstrated. MSC have been applied in several clinical uses. Among them, their ability to improve, and even heal chronic ulcers, as diabetic, has attracted attention for its potential therapeutic impact.

Keywords : Mesenchymal stem cells; soluble factors; wound healing; regeneration; chronic ulcers.

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