Abstract

ROJAS-CONTRERAS, Christian et al. Resistance to ganciclovir in cytomegalovirus infection after heart transplant. Rev. perú. med. exp. salud publica [online]. 2018, vol.35, n.1, pp.145-149. ISSN 1726-4634.  http://dx.doi.org/10.17843/rpmesp.2018.351.3562.

Cytomegalovirus infection after a heart transplant is a recurrent medical condition. Its frequency increases when the donors are serum-positive, and the recipients are serum-negative to this virus. In the pediatric population, the infection only develops in a small percentage and the patients rarely present resistance to conventional treatment with ganciclovir and valganciclovir. We presented the first report of a pediatric case of the cytomegalovirus infection resistant to ganciclovir and valganciclovir after a heart transplant in a Peruvian public hospital with an unusual presentation. The resistance to these drugs was evident after 277 days of evolution of the disease considering the non-remission of the symptomatology and the persistence of an elevated viral load. The administration of foscarnet led to a clinical and laboratory improvement until remission of the disease.

Keywords : Heart transplantation; Pediatría; Virus diseases; Antiviral resistance; Foscarnet; Peru.

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