Resumo

TORIBIO ARIAS, Lesdyth Jessica; SEVILLA ANDRADE, Carlos Raúl  e  GONZALES-ESCALANTE, Edgar. Markers of plasmid resistance to qnr quinolones in clinical isolates of CTX-M beta-lactamases-producing enterobacteria in Lima, Peru. Rev. perú. med. exp. salud publica [online]. 2019, vol.36, n.2, pp.265-269. ISSN 1726-4634.  http://dx.doi.org/10.17843/rpmesp.2019.362.3960.

Aimed at reporting markers of plasmid resistance to qnr quinolones in clinical isolates of CTX-M beta-lactamase-producing enterobacteria, a descriptive study was conducted with isolates from the strain repository of TO-06/09 project of the National Children´s Health Institute. 138 isolates were recovered. Antimicrobial susceptibility was determined by the diffusion disk method, and gene identification by polymerase chain reaction. Of the 138 isolates, 67 (48.5%) were genotypically positive for qnr proteins; of these, 38 (56.7%) had qnrB determinants and 48 (71.6%) had qnrS determinants. No isolate presented qnrA determinants. qnr determinants were detected in isolates containing CTX-M beta-lactamases in a non-exposed population.

Palavras-chave : Bacterial drug resistance; Quinolones; Beta-lactamases; Enterobacteriaceae.

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