SciELO - Scientific Electronic Library Online

vol.36 issue4Factors associated with daytime sleepiness in public transportation drivers in Lima Metropolitan areaTooth brushing and fluoride levels in toothpaste used by peruvian children under 12 years old author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634


VIGO, Aiko; SOLARI, Lely; SANTOS, David  and  PUYEN, Zully M. Mutations conferring resistance to first-line anti-tuberculosis drugs in Peru: a systematic review of the literature. Rev. perú. med. exp. salud publica [online]. 2019, vol.36, n.4, pp.636-645. ISSN 1726-4634.

Objective. To systematize available information regarding mutations that confer resistance to first-line anti-tuberculosis drugs. Materials and Methods. A systematic review of the scientific literature was conducted to identify articles that reported mutations conferring resistance to first-line anti-tuberculosis drugs. This search emphasized resistance to isoniazid and rifampicin drugs in M. tuberculosis strains of Peruvian patients. The search was performed on PubMed and LILACS (Latin American and Caribbean Health Sciences Literature). Results. Fourteen (14) articles were included, of which three reported mutations associated with resistance to isoniazid, six to rifampicin, eight to pyrazinamide and one to ethambutol. All mutations to isoniazid or rifampicin were identified directly or indirectly by the molecular diagnostic test GenoType MTBDRplus® v2.0. The greatest variability of mutations was determined in resistance to pyrazinamide. Conclusions. There is a great variability of mutations associated with resistance to anti-tuberculosis drugs that have been reported in Peru, and they are systematized in this report. These mutations must be taken into account for the development of diagnostic devices or selection of diagnostic tests to be applied in our country.

Keywords : Mycobacterium tuberculosis; Drug Resistance; Genotype; Mutation.

        · abstract in Spanish     · text in Spanish     · English ( pdf ) | Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License