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Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634


YARETA, José et al. Differential expression of circulating micro-RNAs in patients with active and latent tuberculosis. Rev. perú. med. exp. salud publica [online]. 2020, vol.37, n.1, pp.51-56. ISSN 1726-4634.


To analyze the differential expression of miR-21, miR-29a, miR-99b and miR-155 in serum samples from patients with latent tuberculosis (TB) and active TB compared to healthy controls.

Mate rials and Methods:

We used 28 serum samples (9 with active TB, 10 with latent TB and 9 healthy con trols) for the analysis of gene expression by RT-qPCR with Primers and TaqMan probes. The differential expression was calculated by the Livak method using a normalizing gene (RNU-48).


Overex pression of miR-155 was found in people with latent tuberculosis, compared to healthy controls (0.63 vs. 0.01; p value = 0.032).


The miR-155 could be considered a biomarker to differentiate latent TB from active disease. Studies with larger sample sizes are required to corroborate the findings.

Keywords : Latent Tuberculosis; Tuberculosis; microRNAs; Peru.

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