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Revista Peruana de Medicina Experimental y Salud Publica

Print version ISSN 1726-4634

Abstract

FLORES-CORTEZ, Daisy et al. Antitumor activity of vibrio sp. isolated biopolymers in induced breast cancer in rats. Rev. perú. med. exp. salud publica [online]. 2020, vol.37, n.2, pp.246-252. ISSN 1726-4634.  http://dx.doi.org/10.17843/rpmesp.2020.372.4756.

Objective:

To evaluate the antitumor activity of the raw extract from biopolymers isolated from the Vibrio sp. marine bacteria in breast cancer induced by N-Methyl-N-nitrosourea (MNU) in rats.

Materials and methods:

The Vibrio sp. marine bacteria was cultured for seven days, then the raw supernatant was filtered, precipitated and concentrated. MNU was administered in a single dose of 50 mg/kg to 39 Holtzman rats and were daily treated for 9 weeks orally: G1 (n = 13): 0.1 mL/100 g of saline solution; G2 (n = 13): 20 mg/kg of raw extract from Vibrio sp. biopolymers; G3 (n = 13): 100 mg/kg of tamoxifen; G4 (n = 11) received no MNU and only 0.1 mL/100 g of saline solution. Body weight and the appearance of breast tumors identified by palpation were assessed weekly, as well as histopathological examination at the end of treatment.

Results:

Seventy-seven percent of the rats in the G1 group developed tumors from week 7 onwards in an average of 2.2 tumors per animal; in contrast to the group treated with the raw biopolymer extract and tamoxifen; where only one rat (8%) in each group developed tumors after week nine of induction (p = 0.001). The histopathological results support that all the removed tumors correspond to breast ductal adenocarcinoma with different patterns: solid, papillary and cystic. Likewise, necrotic foci were evidenced in 30% of the tumors of the G1 group.

Conclusion:

The raw extract of biopolymers isolated from Vibrio sp. present antitumor effect in breast cancer induced in rats.

Keywords : Biopolymers; Vibrio; Methylnitrosourea; Breast Cancer.

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