SciELO - Scientific Electronic Library Online

 
vol.37 número4Utilidad de la citometría de flujo para la detección de Pseudomonas aeruginosa productoras de metalobetalactamasasEnterobacterales productores de betalactamasas de espectro extendido portadores del gen mcr-1 en Lima, Perú índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Peruana de Medicina Experimental y Salud Publica

versión impresa ISSN 1726-4634

Resumen

QUINO, Willi et al. Resistome and comparative genomics of clinical isolates of diarrheagenic Escherichia coli from Lima, Peru. Rev. perú. med. exp. salud publica [online]. 2020, vol.37, n.4, pp.705-710.  Epub 18-Nov-2020. ISSN 1726-4634.  http://dx.doi.org/10.17843/rpmesp.2020.374.5240.

In order to describe the genomic characteristics related to antimicrobial resistance and comparative genomics of diarrheagenic Escherichia coli (DEC), 14 DEC isolates from the strain collection of the Instituto Nacional de Salud (INS) were subjected to genome sequencing. We used bioinformatic procedures to analyze the obtained sequences in order to look for microbial resistance genes and genetic regions related to pathotypes and phylogroups. Several antimicrobial resistance determinants were detected, but the production of beta-lactamases and mutations associated to quinolone resistance were the most relevant. Additionally, we observed isolates of the same pathotype grouped in different phylogroups. The comparative genomics analysis showed a greater number of orthologous genes in isolates from the same pathotype and phylogroup. In conclusion, DEC isolates from Lima, Peru, showed resistance to multiple drugs; likewise, molecular and phylogenetic diversity was observed in several pathotypes and phylogroups.

Palabras clave : Escherichia coli; Drug resistance; Phylogeny; Genomics.

        · resumen en Español     · texto en Español | Inglés     · Español ( pdf ) | Inglés ( pdf )