Abstract

ORREGO, Miguel A. et al. Procedure for infusion of autologous mitochondria through the carotid artery in porcine brain. Rev. perú. med. exp. salud publica [online]. 2021, vol.38, n.2, pp.345-351.  Epub July 01, 2021. ISSN 1726-4634.  http://dx.doi.org/10.17843/rpmesp.2021.382.7768.

Mitochondria are complex organelles that play a critical role within the cell; mitochondrial dysfunction can result in significant cell damage or death. Previous studies have demonstrated the promising therapeutic effects of autologous mitochondria transplantation into ischemic cardiac tissue; however, few studies have examined the in vivo effects of mitochondria infusion into the brain. The aim of this study is to report a procedure for carotid infusion of autologous mitochondria into porcine brains. By using this infusion technique, we propose that a selective and minimally invasive administration is feasible and may provide benefits in the treatment of various central nervous system disorders.

Keywords : Mitocondria; Microcatheter; Infusion; Carotid; Brain; Porcine.

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