Resumo

GONZALES-RODRIGUEZ, Arturo Octavio et al. Extended-spectrum β-lactamases and virulence factors in uropathogenic Escherichia coli in nursing homes in Lima, Peru. Rev. perú. med. exp. salud publica [online]. 2022, vol.39, n.1, pp.98-103.  Epub 24-Mar-2022. ISSN 1726-4634.  http://dx.doi.org/10.17843/rpmesp.2022.391.8580.

Nursing homes are institutions with high prevalence of urinary tract infections caused by ESBL-producing E. coli with several virulence factors. The aim of this study was to determine the frequency of the bla CTX-M gene and eight virulence genes in 35 ESBL-producing uropathogenic E. coli from six nursing homes in Peru during 2018. Of the E. coli samples, 57.1% (20/35) were carriers of the bla CTX-M gene. Furthermore, we obtained frequencies of 46% (15/35) and 37% (13/35) for hly-alpha and cnf-1, respectively; we also found high presence of the iucC (63%, 22/35), aer (94%, 33/35) and chuA genes (94%, 33/34) as well as a frequency of 46% (16/35) and 91% (32/34) for the pap GII and nanA genes, respectively. The bla CTX-M gene is predominant and a high frequency of exotoxins gives it a competitive advantage for spreading into the bloodstream.

Palavras-chave : Urinary infections; Antibacterials; Beta-Lactam Resistance; Enterobacteriaceae Infections; Nursing Homes; Uropathogenic Escherichia coli; Virulence Factors; Urinary Tract Infections, ß-lactamases.

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