Resumo

PAREDES ANAYA, Mónica et al. Genetic association analysis between SNP rs914458 of protein tyrosine phosphatase, non-receptor type 1(ptpn1) gene and Type 2 Diabetes in Peruvian Population. Horiz. Med. [online]. 2014, vol.14, n.4, pp.31-36. ISSN 1727-558X.

Objective: Evaluate the association between SNP rs914458 (C>G) of PTPN1 gene with T2DM in a population from the urban area of Lima - Peru. Material and Methods: This study included a total of 216 subjects from the urban area of Lima. The number of subjects in control group was 123, and 93 patients diagnosed with type 2 diabetes from Hospital A. Loayza. SNP genotyping was performed by PCR and sequencing using ABI PRISM 310 DNA sequencer. The association analysis was carried out using the web tool SNPStats and five logistic regression models were performed. The effect of genetic association was established with the OR. Results: The frequency of MAF (allele G) was 0.22 in both control and patient groups. The OR values were not different from the reference values considering the respective confidence interval. Conclusion: No significant association was found between the SNP rs914458 and the PTPN1 gene with T2DM for the urban population of Lima - Peru.

Palavras-chave : PTPN1 Gene; sample nucleothic polymorphism (SNP); alelic frequency; genetic association; type 2 diabetes.

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