Resumo

INOCENTE-CAMONES, Miguel Angel et al. Hypoglycemic effect of aqueous and ethanol extracts of Psidium guajava L. (guajava) in alloxan-induced diabetic rats. Horiz. Med. [online]. 2015, vol.15, n.2, pp.41-48. ISSN 1727-558X.

Objective: To evaluate antidiabetic activity of water and ethanol extracts from Psidium guajava L. leaves in alloxan-induced diabetic rats. Material and Methods: Hyperglycemia was induced in albino rats by administering alloxan monohydrate (100 mg/kg i.p.). Water extract at a dose of 250 mg/kg was administered at a single dose, while ethanol extracts at doses of 250 and 500 mg/kg were also administered at a single dose. Blood glucose was determined two hours after administering the extracts.Results: The addition of water and ethanol extracts of Psidium guajava L. tended to decrease the blood glucose concentration. The water extract at a concentration of 250 mg/kg was found to be more potent than ethanol extracts with the lowest mean glucose concentration of 86.67 mg/dL two hours after it was administered. The effect of ethanol extract was only observed at the concentration of 500 mg/kg with a slight decrease in blood glucose. Conclusion: This study indicated a significant antidiabetic activity of water extract of Psidium guajava L. in alloxan induced diabetic rats.

Palavras-chave : Psidium guajava L.; diabetes mellitus; antidiabetic; alloxan; blood glucose.

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