Abstract

GAMARRA OSORIO, Elman Rolando; ARZANI LEZCANO, Deborah Ximena  and  BURGOS GARCIA, Olga Mercedes Viviana. Drug reaction with eosinophilia and systemic symptoms syndrome caused by extended-release carbamazepine: a case report. Horiz. Med. [online]. 2021, vol.21, n.3, e1309. ISSN 1727-558X.  http://dx.doi.org/10.24265/horizmed.2021.v21n3.12.

The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but highly lethal drug hypersensitivity reaction. Thus, it requires an early diagnosis and timely management. We present the case of a 32-year-old female patient with a diagnosis of epilepsy and organic schizophreniform disorder, secondary to viral encephalitis, who was treated with multiple drugs. Three weeks after the addition of extended-release carbamazepine to her usual therapy, the patient presented a diffuse welt-type skin rash, facial edema, fever, lymphadenopathy, leukocytosis with eosinophilia and elevated transaminases. Carbamazepine administration was discontinued, antihistamines and glucocorticoids were administered orally, and the patient showed a remarkable improvement.

Keywords : Drug hypersensitivity syndrome; Carbamazepine; Exanthema; Eosinophilia.

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