Abstract

BELTRAN GARATE, Brady; QUINONES AVILA, Pilar; MORALES LUNA, Domingo  and  COTRINA MONTENEGRO, Esther. FOXP3 expression in T-cell lymphoma: a 47-case study in Edgardo Rebagliati-Martins Hospital; EsSalud, Lima, Peru. Acta méd. peruana [online]. 2009, vol.26, n.2, pp.74-77. ISSN 1728-5917.

Introduction: Foxp3 is a key regulatory gene required for CD25+ and CD4+ regulatory T-cells development and function (Treg), a cell subpopulation specialized in maintaining a balance between immunity and tolerance. Objective: To determine the specificity and prognostic value of Foxp3 expression in T-cell lymphoma. Material and Methods: A retrospective study carried out in 47 patients with T-cell lymphoma in Edgardo Rebagliati-Martins Hospital, EsSalud (Peruvian Social Security), from 1997 to 2004. Results: The expression of Foxp3 in tumoral cells was detected in 8/33 (24%) ATLL (adult t-cell leukemia/lymphoma) cases and in 2/8 (29%) LTPNE cases. There was no statistically significant difference in overall survival between ATLL Foxp3 (+) and ATLL Foxp3 (-). Foxp3 is expressed in different T-cell lymphoma types, and it is not a specific marker for the dientification of ATLL cases. Conclusion: Foxp3 expression can be seen both in ATLL as in LTPNE.

Keywords : Foxp3; T-cell lymphoma; ATLL.

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