SciELO - Scientific Electronic Library Online

 
vol.26 número2Tabaquismo en la población del área de salud de la Universidad Autónoma de Zacatecas, México índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Acta Médica Peruana

versión On-line ISSN 1728-5917

Resumen

BELTRAN GARATE, Brady; QUINONES AVILA, Pilar; MORALES LUNA, Domingo  y  COTRINA MONTENEGRO, Esther. FOXP3 expression in T-cell lymphoma: a 47-case study in Edgardo Rebagliati-Martins Hospital; EsSalud, Lima, Peru. Acta méd. peruana [online]. 2009, vol.26, n.2, pp.74-77. ISSN 1728-5917.

Introduction: Foxp3 is a key regulatory gene required for CD25+ and CD4+ regulatory T-cells development and function (Treg), a cell subpopulation specialized in maintaining a balance between immunity and tolerance. Objective: To determine the specificity and prognostic value of Foxp3 expression in T-cell lymphoma. Material and Methods: A retrospective study carried out in 47 patients with T-cell lymphoma in Edgardo Rebagliati-Martins Hospital, EsSalud (Peruvian Social Security), from 1997 to 2004. Results: The expression of Foxp3 in tumoral cells was detected in 8/33 (24%) ATLL (adult t-cell leukemia/lymphoma) cases and in 2/8 (29%) LTPNE cases. There was no statistically significant difference in overall survival between ATLL Foxp3 (+) and ATLL Foxp3 (-). Foxp3 is expressed in different T-cell lymphoma types, and it is not a specific marker for the dientification of ATLL cases. Conclusion: Foxp3 expression can be seen both in ATLL as in LTPNE.

Palabras clave : Foxp3; T-cell lymphoma; ATLL.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons