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Acta Médica Peruana

versión On-line ISSN 1728-5917


GRAJEDA-ANCCA, Pablo et al. Risk factors associated to clinical respiratory disorder, spirometric and x-ray abnormalities, at six months follow-up in patients with novel influenza A(H1N1). Acta méd. peruana [online]. 2014, vol.31, n.3, pp.138-149. ISSN 1728-5917.

Background. In 2009, in Cusco region was reported 395 cases of Novel Influenza A(H1N1), 15 deaths (lethality rate = 3,8 %), becoming serious public health problem. The post-acute effects are least investigated topics, and still scarce literature; to be important, to study the presence of respiratory dysfunction at six months follow-up. Objective. To determine the risk factors associated (RFA) to clinical respiratory disorder, spirometric and x-ray abnormalities, observed after sixth month follow-up in patients with influenza AH1N1. Methods. A cross sectional study was developed in 118 patients over 14 years old, six months after having influenza AH1N1 confirmed by PCRrt test, no history of lung disease before 2009. Results. Nearly 7 of every 10 of patients had some type of modifications, the spirometric and clinical disorders were most frequent. The disease of risk associated (PR = 4,11 [95%IC = 2,49-6,78], p = 0,0000002), the delay in specific antiviral treatment (PR = 4,56 [95%IC = 2,48-8,37], p = 0,0000001), and the presence of severe acute respiratory infection (SARI) (PR = 11,35 [95%IC = 4,27-30,17], p = 0,0000000) were the RFA to clinical respiratory disorder. The disease of risk associated (PR = 12,52 [95%IC = 2,7-58,08], p = 0,00003) was associated to radiographic abnormalities. The presence of SARI (PR = 1,33 [95%IC = 1,02-1,74], p = 0,04) was associated to spirometric abnormalities. Conclusions. The influenza AH1N1 produces clinical respiratory, spirometric and radiographic abnormalities; which are present six months after the acute episode. There are RFA how the disease of risk associated, delay in the specific treatment, and presence of SARI, that require consideration, to give appropriate treatment and the respective follow, and prevent these abnormalities.

Palabras clave : Influenza A virus; H1N1 subtype; risk.

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